MANTA AIRCRAFT and AVIONORD partner in the development of the ANN platform for medical transportation.

MANTA AIRCRAFT and AVIONORD sign an agreement aimed at developing a version of the Manta ANN platform for rapid Medical Air Transport services.

Sesto Calende, Italy, May 2022 – Manta Aircraft Italia S.r.l. (“Manta Aircraft”), and Avionord S.r.l. (“Avionord”), a private air transport company highly specialized in Medical Air Transport, have entered into an agreement to field in the future as many as 15 hybrid-electric long-range vertical takeoff and landing (eVTOL) aircraft derived from the Manta Aircraft “ANN” platform in medical services configuration. Avionord also invests in Manta Aircraft and takes a stake in the company. Deliveries are expected to start in 2026.

The agreement enables a promising partnership that will foster the development of an ecosystem and

a timely establishment of Advanced Air Mobility. The use of the innovative aircraft platform is planned above all in the area of special transports of organs for transplants, transport of equipment for re-perfusion of organs destined for transplantation as well as for possible rapid-intervention operations. The vertical take-off and landing option, for example to connect helipads from two hospitals in different cities, coupled with the long range and low infrastructure requirements, result in new point-to-point capabilities and economic efficiencies in the regional range, as this solution represents a significant cost saving and noise reduction compared to conventional helicopters.

“We are honored to be working with Manta Aircraft. After analyzing the market and considering our time-critical missions, we see that the Manta ANN platform is today the only eVTOL offering a range of several hundred kms, which is useful for the missions to transport quickly organs for transplantation from one hospital to another, avoiding being dependent on airports and road transport. The ANN eVTOLs will enable us to reduce the transportation time of the organs, that have a limited life when not connected to the dedicated machines, using aircraft with a reduced operating cost,” says Avionord, CEO Eugenio Cremascoli.

Lucas Marchesini, CEO of Manta Aircraft, adds: “We are very pleased of this partnership with Avionord, who have recognized the uniqueness of the ANN platform in terms of range, pushing into the direction of creating a real use case that will contribute to the rapid establishment of Advanced Air Mobility. From the outset, the design of the aircraft was planned for a relevant range and speed in combination with the low infrastructure requirements and overall costs at a fraction of the cost of a helicopter, in order to be suitable for this kind of operations.”

The investment of Avionord in Manta Aircraft follows the investment of other Italian tech companies and of the State-led CDP VC, in the effort to expedite creating an Italian AAM ecosystem. Manta Aircraft is developing a range of performance-oriented hybrid-electric long-range vertical and short take-off and landing air vehicles (heV/STOL) for regional air mobility and plans to begin certification of the first two-seat, multi-purpose model ANN2 in 2023.


From left to right: Michael Mesaric and Lucas Marchesini, Co-Founders of Manta Aircraft, Eugenio

Cremascoli, CEO of Avionord.

Rendering: Moonlight Studios

For further inquiries:

Michael Mesaric, Co-Founder, Head of Marketing & Operations,

Nano robots applied to medicine


Nanorobotics is the field of emerging technologies that creates machines or robots whose components are at or close to the nanometer scale (10−9 meters)1. More specifically, nanorobotics refers to the nanotechnological engineering of the design and construction of nanorobots, these devices having a size of about 0.1 to 10 micrometers and built with nanoscale or molecular components. The names of nanobots, nanoids, nanites, nanomachines or nanomites have also been used to describe these devices that are currently in the research and development phase.

Nanometric-scale technology emerged 50 years ago, creating a new dimension called to revolutionize the world we know, as it allows the molecular structure of materials to be manipulated to change their intrinsic properties and obtain others with revolutionary applications. This discipline, which flourished between the 1960s and 1980s, opens up an immense universe of possibilities for contemporary science and industry and presents a booming global market whose value will exceed 125,000 million dollars in the next five years, according to the Global Nanotechnology Market report .

What is nano robotics?

To answer this question, answer:

Samuel Sanchez 

 2014 MIT  Award Winner (Under 35 Innovator)

Documenting myself in, I was impressed by the applications of these machines on a microscopic scale.

Main applications for nano and micro machines

The applications for these devices seem endless and these are, from my point of view, the most interesting:

  • Cancer treatment : they will allow the identification and destruction of cancer cells in a much more effective and accurate way.
  • Mechanisms for the targeted administration of drugs  for the control and prevention of diseases.
  • Image diagnosis:  creation of nanoparticles that gather in certain tissues so that when scanning the body with magnetic resonance systems, problems such as diabetes can be detected.
  • New sensing devices : With almost unlimited customization properties for sensing functions, nanorobotics is going to provide us with incredible sensing capabilities that we can integrate into our systems to monitor and measure everything around us.
  • Information Storage Devices : A bioengineer and geneticist at Harvard’s Wyss Institute has managed to store 5.5 petabits of data (about 700 terabytes) in a single gram of DNA, surpassing by 1,000 times the previous record for data density storable in DNA.
  • New energy systems:  Nanorobotics could play an important role in developing more efficient renewable energy systems or making our current machines more energy efficient, requiring less energy to run at the same level or with the same energy function at a higher level.
  • Meta super strong materials:  A team at Caltech has developed a new material, made on a nano scale, with interlocking struts. As if it were an Eiffel tower, it is one of the strongest and lightest substances ever created.
  • Smart windows and walls:  electrochromic devices that, depending on the potential applied, change color. They are intended to be used for energy efficient smart windows to control the internal temperature of a room, clean themselves and other applications.
  • icrosponges to clean oceans:  a sponge, made of carbon nanotubes, capable of absorbing contaminants (fertilizers, pesticides, pharmaceuticals…) from the water. This project is three times more efficient than other previous initiatives and its study has been published in the journal Nanotechnology, from IOP Publishing.
  • Replicators or “molecular assemblers ”: devices capable of directing chemical reactions, managing to place reactive molecules with atomic precision.
  • Health sensors : they would monitor blood chemistry, notifying parameters out of control, detecting spoiled food, inflammation in the body and much more.

I was even more impressed when talking about the fight against cancer that this technology can achieve and other applications in medicine.

Introducing the New InsideTracker Mobile App — Pioneering the Next Generation of Personalized Human Performance

It’s here. It’s arrived—the new InsideTracker mobile app.

After years of spirited debates, thousands of hours of scientific research, and countless iterations of designs, we are very proud to announce the achievement of a significant milestone for InsideTracker – the launch of our new iOS mobile app.

Now, InsideTracker customers can experience a new pinnacle of potential, personalization, and performance from your ultra-personalized nutrition system.

With this first of its kind, customer-exclusive app, you can now integrate real-time physiomarker data from your fitness tracker with your existing blood and DNA biomarker data. This unprecedented combination of Blood + DNA + Fitness Tracking data adds an exponential level of precision and customization to your InsideTracker Action Plan.

Fundamentally, it’s a simple equation with profound results. The more data you put into it, the more impact you get out of it.

Finally, a real-time and complete picture of your health and wellness

When we set about to design this new app from the ground up, we knew we had an ambitious task ahead of us, but one that would successfully realize our company vision. Integrate more and more scientifically proven biometric data inputs to deliver real-time, holistic health & wellness insights.

As a super performer, conscious achiever, and longevity seeker, you are actively looking to not only add more fidelity and deeper insights to your plans but also centralize all the growing and disparate sources of quantified data about your bodies. You wanted to measure more precisely, see more clearly, and act more confidently. In the end, understand the relationship, causation, and correlation between these different data points. You spoke, we listened, and it is here!

Additionally, as we dug deeper, our team of InsideTracker behavioral scientists unearthed more insights to inspire and inform our approach.

Building new habits that stick is a tall order for anyone. You must understand conceptually and intellectually “how” to get it done and be inspired, maintain & sustain, and have a systematic routine if you want to make progress in your health journey. The seeming complexity of orchestrating all these elements to drive desired behavior change can be overwhelming all on your own. And while you may have the goal in mind (e.g., strength, endurance, healthy aging), it can seem out of reach to visualize and realize the steps needed to reach that goal.

But with any challenges or speed bumps that come our way, we see opportunity. So we set about to create an elegant, mobile-first solution that addresses these problems head-on and puts the inherent power of InsideTracker right at your fingertips.

The app was created around a simple idea – provide limitless access to your health and wellness data, helping to keep you on track and build the sound habits you need to reach your health & wellness goals.

A host of brand new features were purpose-designed to provide a clearer & comprehensive picture of your health profile, real-time & immediate feedback, and put more customization & control in your hands.

Fitness tracking integration = more precision and personalization

We know that you, our insatiably curious InsideTracker customers, are measuring more and more data from a growing set of sources such as blood, DNA, and physiological biomarkers.

While all of these tell valuable, in-depth, and nuanced stories about what’s going on inside your body, the truth is they come at different times and frequencies.

Blood reflects what’s going on right now, but it’s just not practical or realistic to test daily. DNA can reveal your body’s potential for certain wellness traits, but your genetic blueprint is stable, unchanging and testing is genuinely only a once in a lifetime occasion. Physiological data, such as resting heart rate and sleep, provide motivating reminders of your daily activity and help monitor regular progress, but don’t effectively translate that data to simple, tangible, and effective “So now what?” actions.

The InsideTracker mobile app’s inherent power is its capability to make the whole truly greater than the sum of these individual parts. The simple act of adding fitness tracking data to your blood and genetic biomarkers unlocks never-before-seen dimensions of your InsideTracker Action Plan. Blood biomarkers now come with genetic and physiological insights. Our trusted, science-backed recommendations to improve your blood biomarkers now show how they will help you physiological markers and how your genetics impact both of them.

Sync your Fitbit to InsideTracker to automatically update your latest data, and you are on your way to seeing inside yourself from an entirely new perspective. A note to “other” fitness tracker fans. Yes, we are launching with Fitbit; however, Garmin and Apple Health integrations are next in line coming in early 2021, and more devices in the queue.

Daily and continuous optimization

At the heart of the new InsideTracker iOS app is the PULSE. This dynamic dashboard home base of the app integrates your daily Action Plan with your existing habits. It helps you visualize and plot your InsideTracker recommendations with easy guidance on how and when to incorporate them throughout your day.

These daily readings also feed into your WELLNESS SCORE, a newly calculated metric exclusive to our app that provides a daily snapshot of your progress towards optimizing your body. As you log actions according to your plan and change key physiological markers, you can track and monitor these changes reflected in your Wellness Score. InsideTracker’s data science team designed this proprietary algorithm to apply relative weight to critical changes and actions. Optimizations in your blood biomarkers will have a relatively more substantial effect on your Wellness Score. In contrast, improvements in physiological markers or daily check-ins on your Action Plan will have a somewhat smaller effect. Be sure to monitor your improvements because even those little changes in your Wellness Score will fuel feelings of reward and positively motivate you towards your goals.

And finally, you’ll get hyper-targeted PROTIPS to keep you on track towards your goals. Delivered daily, these nuggets of wisdom are a single, easy to follow, laser-focused recommendation that will have the most significant impact on improving your performance. Currently, PROTIPS are based on simple physiological recommendations, but soon we will be expanding PROTIPS to include nutrition and blood biomarker-based guidance.

More customization and control

InsideTracker’s behavioral science team was hard at work once again, reimagining the levels of flexibility, customization, and control you have over your InsideTracker Action Plan.

Go ahead and start by picking your goal. With thirteen (13) different goals to choose from, you can select the one you want to focus on, and we’ll help guide you to success. Because your body is dynamic, feel free to change your goal at any time.

New to the mobile app, you can now pick an Action Plan approach that fits your style. Do you want to build healthy habits one small step at a time? Choose the “Focused” approach to steadily zone in on your single highest-impact area. Or do you want to maximize your potential with a multi-step plan and make significant progress ASAP? Then choose “Strive” to fast track your plan by hyper-focusing on the top five highest-impact recommendations.

If it feels like there are too many recommendations, then go ahead and remove some. If you feel the spark to take on a few more, go ahead and add some. We put the power in your hands to design your own personal Action Plan’s pace, style, and robustness.

All of this customization culminates in another new key metric, the IMPACT SCORE. Your Impact Score shows you the strength and effectiveness of each recommendation specifically for you, guiding you to select the best habits to follow. The higher the score, the more influential the recommendation. The Impact Score is based on the number of biomarkers impacted by this recommendation, the strength of the science behind it, and the biomarkers’ importance to your goals.

Note that once you have successfully created your Action Plan on the new InsideTracker mobile app, we encourage you to look forward, not backward, because your Action Plan will now only live in your pocket where it rightfully belongs. Additionally, the new data provided by the app’s exclusive WELLNESS SCORE and IMPACT SCORE has created a dramatically improved Action Plan experience with deeper insights and more accountability.

Buy Ultimate + DNA Kit at 25% off— receive a free Fitbit!

he journey is just the beginning

Like your own exploration of personal performance and health & wellness, our commitment to being a beacon of truth in a murky world of misinformation is continuous.

A massive thank you goes out to all the designers, developers, creatives, and scientists whose hard work and dedication developed this novel experience specifically for you.

But more importantly, a huge thank you goes out to you, our intrepid truth-seekers, who inspired us to push the boundaries of possibilities and create something truly novel that has never been seen before.

With open arms, we invite you to join us in the next phase of this revolution and realize your body’s true potential for longer, healthier life.

  • The InsideTracker mobile app integrates data from blood, DNA, and fitness trackers to give you a real-time, holistic snapshot of your health & wellness.
  • New daily, actionable ProTips using your body’s real-time data will be delivered via the InsideTracker mobile app to help you stay on track every day of the week.
  • New Wellness Score provides an instant, digestible view of your progress towards your health and wellness goals.
  • New Impact Scores quantify each recommendation’s effectiveness on improving your biomarkers—specific to your body and goals.
  • The InsideTracker Action Plan that’s always been your guide has been redesigned. Fully customize it, create an approach and style that meets your needs—and have it with you in your pocket at every turn.
  • Currently, the InsideTracker mobile app is available on any iOS device. We are actively developing the Android version for launch in 2021.


How stylish can a walking stick be? How can an MRI station be designed, to achieve the best possible experience for a patient, the easiest working atmosphere for doctors and nurses – and a precise diagnosis at the same time? There is probably no other field as complex and sensitive as medical and healthcare design. With the MEDICA in Düsseldorf just around the corner, we compiled an exclusive medical design special with expert insights!

iF Design Special: Medical Design

Scroll through the best in medical design, read how the complex briefings between designers and medical tech companies succeed, where Big Data and AI are heading and find what character traits the best medical designers have to have!

iF awarded medical and health designs 2019

Get inspired and view all 96 iF awarded medical designs in our iF DESIGN AWARD 2019 collection.

Interview Prof. Detlef Rhein, Muthesius University of Fine Arts and Design: “It is a field of design with general validity”

As one of the most sought-after medical design experts, speakers and professors, German Detlef Rhein knows what good medical design means – and what challenges it poses on young professionals. Read about the role of Artificial Intelligence, pragmatism and radicalism and why designing a plain sofa can be as complex as designing a medical diagnostic tool.

About Detlef Rhein

Detlef Rhein studied Industrial Design at the University of Darmstadt and the State University of California, San Jose. Professional stages while studying include Adam Opel AG and frog design. Later, he started as a designer at wiege GmbH (Wilkhahn Entwicklungsgesellschaft). After many years working in the Netherlands at ninaber / peters / krouwel and then in Hamburg as a partner of npk design, Detlef later founded the design studio open fields together with Till Garthoff. Since 2009 he is professor of industrial design at the Muthesius University of Fine Arts and Design.

iF: Companies have high standards when it comes to the design of their products or solutions for medical and healthcare. There are many components to consider. What are the challenges designers in the medical sector are facing exactly?

DR: The field of medicine, or rather health, is a very complex area. Designers know many facets, not just medical technology, which in turn is also very divergent. Central to the design in this field is certainly the importance of man and his individuality as well as his physical and cognitive condition. It is about empathy and accuracy, a sensitive field, with very different perspectives, demands and needs of professionals, developers, sponsors, patients and relatives. And: It is always about the design of partially highly specialized systems, interfaces and processes in specific contexts and with specific regulations and organizations as a framework.

iF: There is a great need for a purposeful exchange and briefing between designers and companies in this area in particular. After all, it’s about sensitive topics, unlike the design of a sofa. How do you see that?

DR: By the way: the design of a sofa is also a sensitive topic, quite complex and also very interesting. New developments and designs in the field of medicine should be obliged to a central question: Does something in a specific context with the relevant users and actors really work as one had imagined? Is it valid AND resilient? Do you agree with the assumed interaction setting and the declared user experience? Does the whole thing create a new quality or break it off somewhere? You should work together very well, intensively and confidently, and experiment, test, simulate and discard a lot in the development process in order to make good decisions. In fact, briefings always capture only part of the truth, and experience has shown that the results are never really a direct translation of a briefing. What was not yet recognized? That would always be an important question in cooperation. And not to forget: What are strong unique selling points in the market? How can you convince? These key questions should definitely be clarified.

„The treatment of health conditions of all kinds is per se interaction and information design in historically and culturally conditioned knowledge, technology and social contexts.“

iF: How important is design in the medical field anyway? For many, the focus is first and foremost on functionality or diagnostic precision. How can and must design “perform” here?

DR: Basically, medical design has always been there, from the beginnings – if it is understood as the design of relationships in the health context, because the treatment of health conditions of various kinds is per se interaction and information in historically and culturally conditioned knowledge, technology and social contexts. With the differentiation of health care markets, the field of creative activities has also become more differentiated, so we are talking about markets, competition and societal values, that have played an increasingly important role since the late seventies. Today’s medical/health design is at a comparable level, such as the areas of work, leisure or mobility. It now has to meet the high and highest demands of all concerned, not only in function, but in refinement and perception – lack of sensitivity and negligence are no longer an issue. In addition, there is the crucial question of the image of humans, which is built into every project. If it reduces man, makes him an object or activates him and assigns him an individual dimension. For design, this is a fundamental question that needs to be clarified.

iF: You have already been awarded for your seca designs in the past, with your studio open fields. Biotronik is also among your customers. Can you briefly outline your work for the company?

DR: The role of design has changed significantly in cooperation with both companies in the last 10 years. Whereas previously it was more traditional design projects for a hardware design with ergonomic aspects in which Till Garthoff and I worked together, today it is always combined hardware, information or interface designs. How is data collected, processed and presented? Who will deal with the data then? But new measurement and sensor technologies have also been added that dissolve traditional ways of thinking, create completely new product categories, and also demarcate many entrepreneurially as more accurate and comprehensive measurements can be made. We have a new strategic role in the development of possible new fields of application, e.g. in the area of data handling and interface design as well as system innovation.

iF: Big data and AI play an increasing role in the medical / healthcare field, e.g. collect data and analyze it meaningfully for diagnosis or patient information. Also, so-called brain-computer interfaces (BCIs) are a thing tofday! This requires medical tools. How do you encounter this topic so far in your work or at the university?

DR: This is one of the big questions, in which it is important to clarify what desirable qualities are, because data is not a solution to everything and to itself, but actually must be good for something and make sense. Both in my design practice and at the university, there have already been a large number of projects that have addressed this topic, i.e. in cooperation with Siemens. More precisely, it was about the future prospects of mammography or the application of ultrasound. In addition to handling the hardware, the design of the technical images in particular was a question, as KI-based systems are revolutionizing diagnostics and image analysis. How does the communication work then? How is the diagnostic certainty increased? Occupational fields change, for example in radiology. And not to forget: Patients are getting more and more informed. We must ask ourselves: What influence does this have on the doctor-patient relationship in the future, especially if not all information is also substantial or utilisable?

iF: Can you give us your personal three trends, in the field of medical design?

DR: In short, I see the following fields in which we must fundamentally rebuild our understanding: the aging society, the changes in age image and understanding, and the question of technological support in this highly human relationship field. The environment and health complex including climate change and health in a global context (potential threats and rare diseases from distant regions are also beginning to show themselves). And of course there is also the trend of the entire field of e-health and digitization, including remote diagnostics, data processing and information transfer. There will be completely new tools for self-examination that need to be designed. I can not go into the present possibilities of changes of the body by e.g. invasive technologies and genetic engineering.

iF: Some of your students were also honored with our iF DESIGN TALENT AWARD. What are reocurring problems of the students in the design process?

DR: Pragmatism and radicalism are the two antagonists who keep coming back into the ring. Design needs framework conditions, requirements and information in order to orientate oneself and to develop criteria. Where can I get them? Information gathering and analysis is a challenge. On the other hand, these aspects lead to nothing in terms of design, it needs an idea of a new quality, of a change, in short: a new understanding. This is built into every design project. How far do you throw and what compromises do you make? The force of the expert opinions and regulations can be intimidating, I see this currently at work on the reorganization of the emergency department in hospitals. Only visionary strength and posture help here, which one must develop in order to generate substance and bring new qualities into the world. At the end of the day, it’s basically just that and not the kind confirmation of the established.

iF: And what advice would you give your students if they want to specialize in medicine and healthcare?

DR: Provocatively: It is a design area with generality. Understanding people and actors, exploring specific contexts, shaping social and technological change and becoming very sensitive, critical and precise; Coordinate systems, processes and interactions, make information meaningful and create collective value. So, working on truly sustainable “futures” for a healthy life. This skill set is so comprehensive and sophisticated that it basically leaves a lot of future-relevant areas and innovation settings open beyond medicine.